Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
Identifieur interne : 002740 ( Main/Exploration ); précédent : 002739; suivant : 002741Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
Auteurs : Nevan J. Krogan [Canada] ; Gerard Cagney ; Haiyuan Yu ; Gouqing Zhong ; Xinghua Guo ; Alexandr Ignatchenko ; Joyce Li ; Shuye Pu ; Nira Datta ; Aaron P. Tikuisis ; Thanuja Punna ; José M. Peregrín-Alvarez ; Michael Shales ; Xin Zhang ; Michael Davey ; Mark D. Robinson ; Alberto Paccanaro ; James E. Bray ; Anthony Sheung ; Bryan Beattie ; Dawn P. Richards ; Veronica Canadien ; Atanas Lalev ; Frank Mena ; Peter Wong ; Andrei Starostine ; Myra M. Canete ; James Vlasblom ; Samuel Wu ; Chris Orsi ; Sean R. Collins ; Shamanta Chandran ; Robin Haw ; Jennifer J. Rilstone ; Kiran Gandi ; Natalie J. Thompson ; Gabe Musso ; Peter St Onge ; Shaun Ghanny ; Mandy H Y. Lam ; Gareth Butland ; Amin M. Altaf-Ul ; Shigehiko Kanaya ; Ali Shilatifard ; Erin O'Shea ; Jonathan S. Weissman ; C James Ingles ; Timothy R. Hughes ; John Parkinson ; Mark Gerstein ; Shoshana J. Wodak ; Andrew Emili ; Jack F. GreenblattSource :
- Nature [ 1476-4687 ] ; 2006.
English descriptors
- KwdEn :
- Biological Evolution, Conserved Sequence, Mass Spectrometry, Multiprotein Complexes (chemistry), Multiprotein Complexes (metabolism), Protein Binding, Proteome (chemistry), Proteome (metabolism), Proteomics, Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (chemistry), Saccharomyces cerevisiae Proteins (metabolism).
- MESH :
- chemical , chemistry : Multiprotein Complexes, Proteome, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Multiprotein Complexes, Proteome, Saccharomyces cerevisiae Proteins.
- metabolism : Saccharomyces cerevisiae.
- Biological Evolution, Conserved Sequence, Mass Spectrometry, Protein Binding, Proteomics.
Abstract
Identification of protein-protein interactions often provides insight into protein function, and many cellular processes are performed by stable protein complexes. We used tandem affinity purification to process 4,562 different tagged proteins of the yeast Saccharomyces cerevisiae. Each preparation was analysed by both matrix-assisted laser desorption/ionization-time of flight mass spectrometry and liquid chromatography tandem mass spectrometry to increase coverage and accuracy. Machine learning was used to integrate the mass spectrometry scores and assign probabilities to the protein-protein interactions. Among 4,087 different proteins identified with high confidence by mass spectrometry from 2,357 successful purifications, our core data set (median precision of 0.69) comprises 7,123 protein-protein interactions involving 2,708 proteins. A Markov clustering algorithm organized these interactions into 547 protein complexes averaging 4.9 subunits per complex, about half of them absent from the MIPS database, as well as 429 additional interactions between pairs of complexes. The data (all of which are available online) will help future studies on individual proteins as well as functional genomics and systems biology.
DOI: 10.1038/nature04670
PubMed: 16554755
Affiliations:
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Krogan</name><affiliation wicri:level="4"><nlm:affiliation>Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Cagney, Gerard" sort="Cagney, Gerard" uniqKey="Cagney G" first="Gerard" last="Cagney">Gerard Cagney</name></author><author><name sortKey="Yu, Haiyuan" sort="Yu, Haiyuan" uniqKey="Yu H" first="Haiyuan" last="Yu">Haiyuan Yu</name></author><author><name sortKey="Zhong, Gouqing" sort="Zhong, Gouqing" uniqKey="Zhong G" first="Gouqing" last="Zhong">Gouqing Zhong</name></author><author><name sortKey="Guo, Xinghua" sort="Guo, Xinghua" uniqKey="Guo X" first="Xinghua" last="Guo">Xinghua Guo</name></author><author><name sortKey="Ignatchenko, Alexandr" sort="Ignatchenko, Alexandr" uniqKey="Ignatchenko A" first="Alexandr" last="Ignatchenko">Alexandr Ignatchenko</name></author><author><name sortKey="Li, Joyce" sort="Li, Joyce" uniqKey="Li J" first="Joyce" last="Li">Joyce Li</name></author><author><name sortKey="Pu, Shuye" sort="Pu, Shuye" uniqKey="Pu S" first="Shuye" last="Pu">Shuye Pu</name></author><author><name sortKey="Datta, Nira" sort="Datta, Nira" uniqKey="Datta N" first="Nira" last="Datta">Nira Datta</name></author><author><name sortKey="Tikuisis, Aaron P" sort="Tikuisis, Aaron P" uniqKey="Tikuisis A" first="Aaron P" last="Tikuisis">Aaron P. Tikuisis</name></author><author><name sortKey="Punna, Thanuja" sort="Punna, Thanuja" uniqKey="Punna T" first="Thanuja" last="Punna">Thanuja Punna</name></author><author><name sortKey="Peregrin Alvarez, Jose M" sort="Peregrin Alvarez, Jose M" uniqKey="Peregrin Alvarez J" first="José M" last="Peregrín-Alvarez">José M. Peregrín-Alvarez</name></author><author><name sortKey="Shales, Michael" sort="Shales, Michael" uniqKey="Shales M" first="Michael" last="Shales">Michael Shales</name></author><author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name></author><author><name sortKey="Davey, Michael" sort="Davey, Michael" uniqKey="Davey M" first="Michael" last="Davey">Michael Davey</name></author><author><name sortKey="Robinson, Mark D" sort="Robinson, Mark D" uniqKey="Robinson M" first="Mark D" last="Robinson">Mark D. Robinson</name></author><author><name sortKey="Paccanaro, Alberto" sort="Paccanaro, Alberto" uniqKey="Paccanaro A" first="Alberto" last="Paccanaro">Alberto Paccanaro</name></author><author><name sortKey="Bray, James E" sort="Bray, James E" uniqKey="Bray J" first="James E" last="Bray">James E. Bray</name></author><author><name sortKey="Sheung, Anthony" sort="Sheung, Anthony" uniqKey="Sheung A" first="Anthony" last="Sheung">Anthony Sheung</name></author><author><name sortKey="Beattie, Bryan" sort="Beattie, Bryan" uniqKey="Beattie B" first="Bryan" last="Beattie">Bryan Beattie</name></author><author><name sortKey="Richards, Dawn P" sort="Richards, Dawn P" uniqKey="Richards D" first="Dawn P" last="Richards">Dawn P. Richards</name></author><author><name sortKey="Canadien, Veronica" sort="Canadien, Veronica" uniqKey="Canadien V" first="Veronica" last="Canadien">Veronica Canadien</name></author><author><name sortKey="Lalev, Atanas" sort="Lalev, Atanas" uniqKey="Lalev A" first="Atanas" last="Lalev">Atanas Lalev</name></author><author><name sortKey="Mena, Frank" sort="Mena, Frank" uniqKey="Mena F" first="Frank" last="Mena">Frank Mena</name></author><author><name sortKey="Wong, Peter" sort="Wong, Peter" uniqKey="Wong P" first="Peter" last="Wong">Peter Wong</name></author><author><name sortKey="Starostine, Andrei" sort="Starostine, Andrei" uniqKey="Starostine A" first="Andrei" last="Starostine">Andrei Starostine</name></author><author><name sortKey="Canete, Myra M" sort="Canete, Myra M" uniqKey="Canete M" first="Myra M" last="Canete">Myra M. Canete</name></author><author><name sortKey="Vlasblom, James" sort="Vlasblom, James" uniqKey="Vlasblom J" first="James" last="Vlasblom">James Vlasblom</name></author><author><name sortKey="Wu, Samuel" sort="Wu, Samuel" uniqKey="Wu S" first="Samuel" last="Wu">Samuel Wu</name></author><author><name sortKey="Orsi, Chris" sort="Orsi, Chris" uniqKey="Orsi C" first="Chris" last="Orsi">Chris Orsi</name></author><author><name sortKey="Collins, Sean R" sort="Collins, Sean R" uniqKey="Collins S" first="Sean R" last="Collins">Sean R. Collins</name></author><author><name sortKey="Chandran, Shamanta" sort="Chandran, Shamanta" uniqKey="Chandran S" first="Shamanta" last="Chandran">Shamanta Chandran</name></author><author><name sortKey="Haw, Robin" sort="Haw, Robin" uniqKey="Haw R" first="Robin" last="Haw">Robin Haw</name></author><author><name sortKey="Rilstone, Jennifer J" sort="Rilstone, Jennifer J" uniqKey="Rilstone J" first="Jennifer J" last="Rilstone">Jennifer J. 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Weissman</name></author><author><name sortKey="Ingles, C James" sort="Ingles, C James" uniqKey="Ingles C" first="C James" last="Ingles">C James Ingles</name></author><author><name sortKey="Hughes, Timothy R" sort="Hughes, Timothy R" uniqKey="Hughes T" first="Timothy R" last="Hughes">Timothy R. Hughes</name></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></author><author><name sortKey="Gerstein, Mark" sort="Gerstein, Mark" uniqKey="Gerstein M" first="Mark" last="Gerstein">Mark Gerstein</name></author><author><name sortKey="Wodak, Shoshana J" sort="Wodak, Shoshana J" uniqKey="Wodak S" first="Shoshana J" last="Wodak">Shoshana J. 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Krogan</name><affiliation wicri:level="4"><nlm:affiliation>Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Cagney, Gerard" sort="Cagney, Gerard" uniqKey="Cagney G" first="Gerard" last="Cagney">Gerard Cagney</name></author><author><name sortKey="Yu, Haiyuan" sort="Yu, Haiyuan" uniqKey="Yu H" first="Haiyuan" last="Yu">Haiyuan Yu</name></author><author><name sortKey="Zhong, Gouqing" sort="Zhong, Gouqing" uniqKey="Zhong G" first="Gouqing" last="Zhong">Gouqing Zhong</name></author><author><name sortKey="Guo, Xinghua" sort="Guo, Xinghua" uniqKey="Guo X" first="Xinghua" last="Guo">Xinghua Guo</name></author><author><name sortKey="Ignatchenko, Alexandr" sort="Ignatchenko, Alexandr" uniqKey="Ignatchenko A" first="Alexandr" last="Ignatchenko">Alexandr Ignatchenko</name></author><author><name sortKey="Li, Joyce" sort="Li, Joyce" uniqKey="Li J" first="Joyce" last="Li">Joyce Li</name></author><author><name sortKey="Pu, Shuye" sort="Pu, Shuye" uniqKey="Pu S" first="Shuye" last="Pu">Shuye Pu</name></author><author><name sortKey="Datta, Nira" sort="Datta, Nira" uniqKey="Datta N" first="Nira" last="Datta">Nira Datta</name></author><author><name sortKey="Tikuisis, Aaron P" sort="Tikuisis, Aaron P" uniqKey="Tikuisis A" first="Aaron P" last="Tikuisis">Aaron P. Tikuisis</name></author><author><name sortKey="Punna, Thanuja" sort="Punna, Thanuja" uniqKey="Punna T" first="Thanuja" last="Punna">Thanuja Punna</name></author><author><name sortKey="Peregrin Alvarez, Jose M" sort="Peregrin Alvarez, Jose M" uniqKey="Peregrin Alvarez J" first="José M" last="Peregrín-Alvarez">José M. Peregrín-Alvarez</name></author><author><name sortKey="Shales, Michael" sort="Shales, Michael" uniqKey="Shales M" first="Michael" last="Shales">Michael Shales</name></author><author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name></author><author><name sortKey="Davey, Michael" sort="Davey, Michael" uniqKey="Davey M" first="Michael" last="Davey">Michael Davey</name></author><author><name sortKey="Robinson, Mark D" sort="Robinson, Mark D" uniqKey="Robinson M" first="Mark D" last="Robinson">Mark D. Robinson</name></author><author><name sortKey="Paccanaro, Alberto" sort="Paccanaro, Alberto" uniqKey="Paccanaro A" first="Alberto" last="Paccanaro">Alberto Paccanaro</name></author><author><name sortKey="Bray, James E" sort="Bray, James E" uniqKey="Bray J" first="James E" last="Bray">James E. Bray</name></author><author><name sortKey="Sheung, Anthony" sort="Sheung, Anthony" uniqKey="Sheung A" first="Anthony" last="Sheung">Anthony Sheung</name></author><author><name sortKey="Beattie, Bryan" sort="Beattie, Bryan" uniqKey="Beattie B" first="Bryan" last="Beattie">Bryan Beattie</name></author><author><name sortKey="Richards, Dawn P" sort="Richards, Dawn P" uniqKey="Richards D" first="Dawn P" last="Richards">Dawn P. Richards</name></author><author><name sortKey="Canadien, Veronica" sort="Canadien, Veronica" uniqKey="Canadien V" first="Veronica" last="Canadien">Veronica Canadien</name></author><author><name sortKey="Lalev, Atanas" sort="Lalev, Atanas" uniqKey="Lalev A" first="Atanas" last="Lalev">Atanas Lalev</name></author><author><name sortKey="Mena, Frank" sort="Mena, Frank" uniqKey="Mena F" first="Frank" last="Mena">Frank Mena</name></author><author><name sortKey="Wong, Peter" sort="Wong, Peter" uniqKey="Wong P" first="Peter" last="Wong">Peter Wong</name></author><author><name sortKey="Starostine, Andrei" sort="Starostine, Andrei" uniqKey="Starostine A" first="Andrei" last="Starostine">Andrei Starostine</name></author><author><name sortKey="Canete, Myra M" sort="Canete, Myra M" uniqKey="Canete M" first="Myra M" last="Canete">Myra M. Canete</name></author><author><name sortKey="Vlasblom, James" sort="Vlasblom, James" uniqKey="Vlasblom J" first="James" last="Vlasblom">James Vlasblom</name></author><author><name sortKey="Wu, Samuel" sort="Wu, Samuel" uniqKey="Wu S" first="Samuel" last="Wu">Samuel Wu</name></author><author><name sortKey="Orsi, Chris" sort="Orsi, Chris" uniqKey="Orsi C" first="Chris" last="Orsi">Chris Orsi</name></author><author><name sortKey="Collins, Sean R" sort="Collins, Sean R" uniqKey="Collins S" first="Sean R" last="Collins">Sean R. Collins</name></author><author><name sortKey="Chandran, Shamanta" sort="Chandran, Shamanta" uniqKey="Chandran S" first="Shamanta" last="Chandran">Shamanta Chandran</name></author><author><name sortKey="Haw, Robin" sort="Haw, Robin" uniqKey="Haw R" first="Robin" last="Haw">Robin Haw</name></author><author><name sortKey="Rilstone, Jennifer J" sort="Rilstone, Jennifer J" uniqKey="Rilstone J" first="Jennifer J" last="Rilstone">Jennifer J. Rilstone</name></author><author><name sortKey="Gandi, Kiran" sort="Gandi, Kiran" uniqKey="Gandi K" first="Kiran" last="Gandi">Kiran Gandi</name></author><author><name sortKey="Thompson, Natalie J" sort="Thompson, Natalie J" uniqKey="Thompson N" first="Natalie J" last="Thompson">Natalie J. Thompson</name></author><author><name sortKey="Musso, Gabe" sort="Musso, Gabe" uniqKey="Musso G" first="Gabe" last="Musso">Gabe Musso</name></author><author><name sortKey="St Onge, Peter" sort="St Onge, Peter" uniqKey="St Onge P" first="Peter" last="St Onge">Peter St Onge</name></author><author><name sortKey="Ghanny, Shaun" sort="Ghanny, Shaun" uniqKey="Ghanny S" first="Shaun" last="Ghanny">Shaun Ghanny</name></author><author><name sortKey="Lam, Mandy H Y" sort="Lam, Mandy H Y" uniqKey="Lam M" first="Mandy H Y" last="Lam">Mandy H Y. Lam</name></author><author><name sortKey="Butland, Gareth" sort="Butland, Gareth" uniqKey="Butland G" first="Gareth" last="Butland">Gareth Butland</name></author><author><name sortKey="Altaf Ul, Amin M" sort="Altaf Ul, Amin M" uniqKey="Altaf Ul A" first="Amin M" last="Altaf-Ul">Amin M. Altaf-Ul</name></author><author><name sortKey="Kanaya, Shigehiko" sort="Kanaya, Shigehiko" uniqKey="Kanaya S" first="Shigehiko" last="Kanaya">Shigehiko Kanaya</name></author><author><name sortKey="Shilatifard, Ali" sort="Shilatifard, Ali" uniqKey="Shilatifard A" first="Ali" last="Shilatifard">Ali Shilatifard</name></author><author><name sortKey="O Shea, Erin" sort="O Shea, Erin" uniqKey="O Shea E" first="Erin" last="O'Shea">Erin O'Shea</name></author><author><name sortKey="Weissman, Jonathan S" sort="Weissman, Jonathan S" uniqKey="Weissman J" first="Jonathan S" last="Weissman">Jonathan S. Weissman</name></author><author><name sortKey="Ingles, C James" sort="Ingles, C James" uniqKey="Ingles C" first="C James" last="Ingles">C James Ingles</name></author><author><name sortKey="Hughes, Timothy R" sort="Hughes, Timothy R" uniqKey="Hughes T" first="Timothy R" last="Hughes">Timothy R. Hughes</name></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></author><author><name sortKey="Gerstein, Mark" sort="Gerstein, Mark" uniqKey="Gerstein M" first="Mark" last="Gerstein">Mark Gerstein</name></author><author><name sortKey="Wodak, Shoshana J" sort="Wodak, Shoshana J" uniqKey="Wodak S" first="Shoshana J" last="Wodak">Shoshana J. Wodak</name></author><author><name sortKey="Emili, Andrew" sort="Emili, Andrew" uniqKey="Emili A" first="Andrew" last="Emili">Andrew Emili</name></author><author><name sortKey="Greenblatt, Jack F" sort="Greenblatt, Jack F" uniqKey="Greenblatt J" first="Jack F" last="Greenblatt">Jack F. Greenblatt</name></author></analytic><series><title level="j">Nature</title><idno type="eISSN">1476-4687</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological Evolution</term><term>Conserved Sequence</term><term>Mass Spectrometry</term><term>Multiprotein Complexes (chemistry)</term><term>Multiprotein Complexes (metabolism)</term><term>Protein Binding</term><term>Proteome (chemistry)</term><term>Proteome (metabolism)</term><term>Proteomics</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (chemistry)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Multiprotein Complexes</term><term>Proteome</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Multiprotein Complexes</term><term>Proteome</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biological Evolution</term><term>Conserved Sequence</term><term>Mass Spectrometry</term><term>Protein Binding</term><term>Proteomics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Identification of protein-protein interactions often provides insight into protein function, and many cellular processes are performed by stable protein complexes. We used tandem affinity purification to process 4,562 different tagged proteins of the yeast Saccharomyces cerevisiae. Each preparation was analysed by both matrix-assisted laser desorption/ionization-time of flight mass spectrometry and liquid chromatography tandem mass spectrometry to increase coverage and accuracy. Machine learning was used to integrate the mass spectrometry scores and assign probabilities to the protein-protein interactions. Among 4,087 different proteins identified with high confidence by mass spectrometry from 2,357 successful purifications, our core data set (median precision of 0.69) comprises 7,123 protein-protein interactions involving 2,708 proteins. A Markov clustering algorithm organized these interactions into 547 protein complexes averaging 4.9 subunits per complex, about half of them absent from the MIPS database, as well as 429 additional interactions between pairs of complexes. The data (all of which are available online) will help future studies on individual proteins as well as functional genomics and systems biology.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Altaf Ul, Amin M" sort="Altaf Ul, Amin M" uniqKey="Altaf Ul A" first="Amin M" last="Altaf-Ul">Amin M. Altaf-Ul</name><name sortKey="Beattie, Bryan" sort="Beattie, Bryan" uniqKey="Beattie B" first="Bryan" last="Beattie">Bryan Beattie</name><name sortKey="Bray, James E" sort="Bray, James E" uniqKey="Bray J" first="James E" last="Bray">James E. Bray</name><name sortKey="Butland, Gareth" sort="Butland, Gareth" uniqKey="Butland G" first="Gareth" last="Butland">Gareth Butland</name><name sortKey="Cagney, Gerard" sort="Cagney, Gerard" uniqKey="Cagney G" first="Gerard" last="Cagney">Gerard Cagney</name><name sortKey="Canadien, Veronica" sort="Canadien, Veronica" uniqKey="Canadien V" first="Veronica" last="Canadien">Veronica Canadien</name><name sortKey="Canete, Myra M" sort="Canete, Myra M" uniqKey="Canete M" first="Myra M" last="Canete">Myra M. Canete</name><name sortKey="Chandran, Shamanta" sort="Chandran, Shamanta" uniqKey="Chandran S" first="Shamanta" last="Chandran">Shamanta Chandran</name><name sortKey="Collins, Sean R" sort="Collins, Sean R" uniqKey="Collins S" first="Sean R" last="Collins">Sean R. Collins</name><name sortKey="Datta, Nira" sort="Datta, Nira" uniqKey="Datta N" first="Nira" last="Datta">Nira Datta</name><name sortKey="Davey, Michael" sort="Davey, Michael" uniqKey="Davey M" first="Michael" last="Davey">Michael Davey</name><name sortKey="Emili, Andrew" sort="Emili, Andrew" uniqKey="Emili A" first="Andrew" last="Emili">Andrew Emili</name><name sortKey="Gandi, Kiran" sort="Gandi, Kiran" uniqKey="Gandi K" first="Kiran" last="Gandi">Kiran Gandi</name><name sortKey="Gerstein, Mark" sort="Gerstein, Mark" uniqKey="Gerstein M" first="Mark" last="Gerstein">Mark Gerstein</name><name sortKey="Ghanny, Shaun" sort="Ghanny, Shaun" uniqKey="Ghanny S" first="Shaun" last="Ghanny">Shaun Ghanny</name><name sortKey="Greenblatt, Jack F" sort="Greenblatt, Jack F" uniqKey="Greenblatt J" first="Jack F" last="Greenblatt">Jack F. Greenblatt</name><name sortKey="Guo, Xinghua" sort="Guo, Xinghua" uniqKey="Guo X" first="Xinghua" last="Guo">Xinghua Guo</name><name sortKey="Haw, Robin" sort="Haw, Robin" uniqKey="Haw R" first="Robin" last="Haw">Robin Haw</name><name sortKey="Hughes, Timothy R" sort="Hughes, Timothy R" uniqKey="Hughes T" first="Timothy R" last="Hughes">Timothy R. Hughes</name><name sortKey="Ignatchenko, Alexandr" sort="Ignatchenko, Alexandr" uniqKey="Ignatchenko A" first="Alexandr" last="Ignatchenko">Alexandr Ignatchenko</name><name sortKey="Ingles, C James" sort="Ingles, C James" uniqKey="Ingles C" first="C James" last="Ingles">C James Ingles</name><name sortKey="Kanaya, Shigehiko" sort="Kanaya, Shigehiko" uniqKey="Kanaya S" first="Shigehiko" last="Kanaya">Shigehiko Kanaya</name><name sortKey="Lalev, Atanas" sort="Lalev, Atanas" uniqKey="Lalev A" first="Atanas" last="Lalev">Atanas Lalev</name><name sortKey="Lam, Mandy H Y" sort="Lam, Mandy H Y" uniqKey="Lam M" first="Mandy H Y" last="Lam">Mandy H Y. Lam</name><name sortKey="Li, Joyce" sort="Li, Joyce" uniqKey="Li J" first="Joyce" last="Li">Joyce Li</name><name sortKey="Mena, Frank" sort="Mena, Frank" uniqKey="Mena F" first="Frank" last="Mena">Frank Mena</name><name sortKey="Musso, Gabe" sort="Musso, Gabe" uniqKey="Musso G" first="Gabe" last="Musso">Gabe Musso</name><name sortKey="O Shea, Erin" sort="O Shea, Erin" uniqKey="O Shea E" first="Erin" last="O'Shea">Erin O'Shea</name><name sortKey="Orsi, Chris" sort="Orsi, Chris" uniqKey="Orsi C" first="Chris" last="Orsi">Chris Orsi</name><name sortKey="Paccanaro, Alberto" sort="Paccanaro, Alberto" uniqKey="Paccanaro A" first="Alberto" last="Paccanaro">Alberto Paccanaro</name><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><name sortKey="Peregrin Alvarez, Jose M" sort="Peregrin Alvarez, Jose M" uniqKey="Peregrin Alvarez J" first="José M" last="Peregrín-Alvarez">José M. Peregrín-Alvarez</name><name sortKey="Pu, Shuye" sort="Pu, Shuye" uniqKey="Pu S" first="Shuye" last="Pu">Shuye Pu</name><name sortKey="Punna, Thanuja" sort="Punna, Thanuja" uniqKey="Punna T" first="Thanuja" last="Punna">Thanuja Punna</name><name sortKey="Richards, Dawn P" sort="Richards, Dawn P" uniqKey="Richards D" first="Dawn P" last="Richards">Dawn P. Richards</name><name sortKey="Rilstone, Jennifer J" sort="Rilstone, Jennifer J" uniqKey="Rilstone J" first="Jennifer J" last="Rilstone">Jennifer J. Rilstone</name><name sortKey="Robinson, Mark D" sort="Robinson, Mark D" uniqKey="Robinson M" first="Mark D" last="Robinson">Mark D. Robinson</name><name sortKey="Shales, Michael" sort="Shales, Michael" uniqKey="Shales M" first="Michael" last="Shales">Michael Shales</name><name sortKey="Sheung, Anthony" sort="Sheung, Anthony" uniqKey="Sheung A" first="Anthony" last="Sheung">Anthony Sheung</name><name sortKey="Shilatifard, Ali" sort="Shilatifard, Ali" uniqKey="Shilatifard A" first="Ali" last="Shilatifard">Ali Shilatifard</name><name sortKey="St Onge, Peter" sort="St Onge, Peter" uniqKey="St Onge P" first="Peter" last="St Onge">Peter St Onge</name><name sortKey="Starostine, Andrei" sort="Starostine, Andrei" uniqKey="Starostine A" first="Andrei" last="Starostine">Andrei Starostine</name><name sortKey="Thompson, Natalie J" sort="Thompson, Natalie J" uniqKey="Thompson N" first="Natalie J" last="Thompson">Natalie J. Thompson</name><name sortKey="Tikuisis, Aaron P" sort="Tikuisis, Aaron P" uniqKey="Tikuisis A" first="Aaron P" last="Tikuisis">Aaron P. Tikuisis</name><name sortKey="Vlasblom, James" sort="Vlasblom, James" uniqKey="Vlasblom J" first="James" last="Vlasblom">James Vlasblom</name><name sortKey="Weissman, Jonathan S" sort="Weissman, Jonathan S" uniqKey="Weissman J" first="Jonathan S" last="Weissman">Jonathan S. Weissman</name><name sortKey="Wodak, Shoshana J" sort="Wodak, Shoshana J" uniqKey="Wodak S" first="Shoshana J" last="Wodak">Shoshana J. Wodak</name><name sortKey="Wong, Peter" sort="Wong, Peter" uniqKey="Wong P" first="Peter" last="Wong">Peter Wong</name><name sortKey="Wu, Samuel" sort="Wu, Samuel" uniqKey="Wu S" first="Samuel" last="Wu">Samuel Wu</name><name sortKey="Yu, Haiyuan" sort="Yu, Haiyuan" uniqKey="Yu H" first="Haiyuan" last="Yu">Haiyuan Yu</name><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name><name sortKey="Zhong, Gouqing" sort="Zhong, Gouqing" uniqKey="Zhong G" first="Gouqing" last="Zhong">Gouqing Zhong</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Krogan, Nevan J" sort="Krogan, Nevan J" uniqKey="Krogan N" first="Nevan J" last="Krogan">Nevan J. Krogan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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